منابع مشابه
Metabolic enzymes as oncogenes or tumor suppressors.
n engl j med 360;8 nejm.org february 19, 2009 813 medicines should be an overarching goal for pharmacotherapy over the next decade. Pharmacogenetics has the potential to increase benefit and reduce harm in people whose drug responses are not “average.” In some cases, randomized, controlled trials will be needed to determine whether pharmacogenetic testing is worthwhile; in others, less rigorous...
متن کاملAngiomotin Family Members: Oncogenes or Tumor Suppressors?
Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and the regulation of tight junctions, polarity, and epithelial-mesenchymal transition in epithelial cells. Moreover, these proteins regulate the proliferation and ...
متن کاملId-1 and Id-2 proteins as molecular markers for human prostate cancer progression.
PURPOSE Id proteins are dominant-negative regulators of basic helix-loop-helix transcription factors that control malignant cell behavior in many different tissues. This study aimed to identify the potential role of Id-1 and Id-2 proteins as molecular makers for prostate cancer progression. EXPERIMENTAL DESIGN Using the technique of immunohistochemistry, we determined Id-1 and Id-2 expression...
متن کاملOncogenes and Tumor Suppressors
Our understanding of estrogen (17b-estradiol, E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein–coupled estrogen receptor (GPER/GPR30) and the development of GPER-selective functional chemical probes. GPER is highly expressed in certain breast, endometrial, and ovarian cancers, establishing the importance of noninvas...
متن کاملOncogenes of DNA Tumor Viruses1
Experiments carried out over the past 10-12 years have created a field or approach which may properly be termed the molecular basis of cancer. One of its major accomplishments has been the identification and understanding of some of the functions of a group of cancer-causing genes, the oncogenes. The major path to the oncogenes came from the study of cancercausing viruses. The oncogenes have be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2002
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.50